2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2085
    WWamide-3 149636-89-5 98%
    WWamide-3 is a neuropeptide, which can be isolated form Achatina fulica. WWamide-3 inhibits the rhythmic contraction of anterior byssus retractor muscle (ABRM).
    WWamide-3
  • HY-P2111
    Achatin I 121912-19-4 98%
    Achatin I is a neuroexcitatory tetrapeptide. Achatin I can be derived from Achatina fulica férussac. Achatin-I induces a voltage-dependent inward current. Achatin-I shows marked excitatory effects on the three Achatina giant neurones, PON, TAN and V-RCDN.
    Achatin I
  • HY-P2113
    ORG-2766 50913-82-1 98%
    ORG-2766 is an adrenocorticotropic hormone ACTH 4-9 analog and neurotrophic peptide. ORG-2766 affects behavioral processes such as memory and attention in animals, improving symptoms in rats with experimental allergic neuritis. ORG-2766 has a neuroprotective effect.
    ORG-2766
  • HY-P2121
    JMV 176 119068-32-5 98%
    Jmv 176 is a CCK agonist when first given and becomes a cholecystokinin antagonist after 3-4 hours.
    JMV 176
  • HY-P2135
    Neuropeptide AF1 130092-56-7 98%
    Neuropeptide AF1 is a FMRFamide-like neuropeptide. Neuropeptide AF1 can be isolated from head extracts of the nematode Ascaris suum. Neuropeptide AF1 rapidly and reversibly abolishs slow membrane potential oscillations of identified ventral and dorsal inhibitory motoneurons and selectively reduces their input resistances. Neuropeptide AF1 inhibits locomotory movements in intact Ascaris.
    Neuropeptide AF1
  • HY-P2150
    Cortistatin-29 (rat) 1815618-17-7 98%
    Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.
    Cortistatin-29 (rat)
  • HY-P2165
    N-acetyl CCK-(26-30) amide 89911-69-3 98%
    N-acetyl CCK-(26-30) amide (CCK-(26-30) (sulfated)) is a cholecystokinin (CCK) receptor antagonist.
    N-acetyl CCK-(26-30) amide
  • HY-P2169
    Small cardioactive peptide A 98035-79-1 98%
    Small cardioactive peptide A (SCPA) is a neuropeptide that can be obtained from Aplysia.
    Small cardioactive peptide A
  • HY-P2183
    PEN(mouse) 1236955-25-1 98%
    PEN(mouse) (proSAAS(221-242)) is the precursor of a number of peptides that function as neuropeptides.
    PEN(mouse)
  • HY-P2199
    SNF 9007 137415-20-4 98%
    SNF 9007 is a cholecystokinin analog. SNF 9007 induces analgesia by acting on δ-1, δ-2, and μ opioid receptors in the mouse brain.
    SNF 9007
  • HY-P2204
    PD-149163 169528-11-4 98%
    PD-149163 is an NTR-1 agonist. PD-149163 reverses intestinal damage through its anti-inflammatory, antioxidant, and cell proliferation promoting properties. PD-149163 has antipsychotic effects. PD-149163 is commonly used in research on mental illness and intestinal injury.
    PD-149163
  • HY-P2242
    RO27-3225 274682-89-2 98%
    RO27-3225 is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 shows 30-fold selectivity for MC4R over MC3R. RO27-3225 has neuroprotective and anti-inflammatory effects.
    RO27-3225
  • HY-P2298
    TAT-P4-(DATC5)2 98%
    TAT-P4-(DATC5)2 is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a Ki of 1.7 nM. TAT-P4-(DATC5)2 can inhibit addiction in rats.
    TAT-P4-(DATC5)2
  • HY-P2342
    Angiopep-Bim BH3 hydrochloride 98%
    Angiopep-Bim BH3 hydrochloride, a BBB penetrated peptode, could be used to investigate the permeability of CNS therapeutics.
    Angiopep-Bim BH3 hydrochloride
  • HY-P2374
    Ac-DMQD-CHO 259199-63-8 98%
    Ac-DMQD-CHO is a selective inhibitor for caspase 3, with IC50 of 39 nM. Ac-DMQD-CHO reduces apoptosis, and exhibits neuroprotective efficacy.
    Ac-DMQD-CHO
  • HY-P2428
    RI-61 95034-26-7 98%
    RI-61 is a compound that has activity in suppressing migraine, cluster headache, new daily persistent headache and cyclical vomiting syndrome. RI-61 has shown significant efficacy in relieving the symptoms of these disorders. RI-61 helps relieve pain and other related symptoms by modulating the action of neurotransmitters.
    RI-61
  • HY-P2434
    AP102 846569-60-6 98%
    AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC50: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research.
    AP102
  • HY-P2436
    L-659837 125989-10-8 98%
    L-659837 is a NK2 receptor antagonist, and can antagonize GR 64349 (HY-P1278)-induced contraction. L-659837 can be used for study of urinary bladder disorders.
    L-659837
  • HY-P2475
    [Pro9]-Substance P 104486-69-3 98%
    [Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC50 of 0.93 nM.
    [Pro9]-Substance P
  • HY-P2550
    β-Amyloid (1-40), FAM-labeled 1678416-08-4 98%
    β-Amyloid (1-40), FAM-labeled is a FAM fluorescently-labelled β-Amyloid (1-40) peptide (λex= 492 nm and λem= 518 nm).
    β-Amyloid (1-40), FAM-labeled
Cat. No. Product Name / Synonyms Application Reactivity